PC-CAT Fusion FISH Probe
The PC-CAT Fusion FISH Probe is used to confirm a fusion of the PC and CAT genes. The fusion of the PC and CAT genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PC-CAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PC-CAT-20-RERE | 20 (40 μL) | 200 μL |
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| PC-CAT-20-REOR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-REGO | 20 (40 μL) | 200 μL |
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| PC-CAT-20-REGR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-REAQ | 20 (40 μL) | 200 μL |
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| PC-CAT-20-ORRE | 20 (40 μL) | 200 μL |
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| PC-CAT-20-OROR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-ORGO | 20 (40 μL) | 200 μL |
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| PC-CAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GORE | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GOOR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GOGO | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GOGR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GRRE | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GROR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GRGO | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GRGR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| PC-CAT-20-AQRE | 20 (40 μL) | 200 μL |
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| PC-CAT-20-AQOR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-AQGO | 20 (40 μL) | 200 μL |
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| PC-CAT-20-AQGR | 20 (40 μL) | 200 μL |
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| PC-CAT-20-AQAQ | 20 (40 μL) | 200 μL |
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CAT Gene Summary
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Gene Name: Catalase
Chromosome: CHR11: 34460471 -34493607
Locus: 11p13
PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
Gene Diseases
The PC CAT Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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