PC-CTTN Fusion FISH Probe
The PC-CTTN Fusion FISH Probe is used to confirm a fusion of the PC and CTTN genes. The fusion of the PC and CTTN genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PC-CTTN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-RERE | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-REOR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-REGO | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-REGR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-REAQ | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-ORRE | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-OROR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-ORGO | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-ORAQ | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GORE | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GOOR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GOGO | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GOGR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GOAQ | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GRRE | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GROR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GRGO | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GRGR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-GRAQ | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-AQRE | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-AQOR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-AQGO | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-AQGR | 20 (40 μL) | 200 μL |
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| PC-CTTN-20-AQAQ | 20 (40 μL) | 200 μL |
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CTTN Gene Summary
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Name: Cortactin
Chromosome: CHR11: 70244611 -70282690
Locus: 11q13.3
PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
Gene Diseases
The PC CTTN Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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