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PC-DCDC2 Fusion FISH Probe

The PC-DCDC2 Fusion FISH Probe is used to confirm a fusion of the PC and DCDC2 genes. The fusion of the PC and DCDC2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PC-DCDC2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PC-DCDC2-20-RERE 20 (40 μL) 200 μL
PC-DCDC2-20-REOR 20 (40 μL) 200 μL
PC-DCDC2-20-REGO 20 (40 μL) 200 μL
PC-DCDC2-20-REGR 20 (40 μL) 200 μL
PC-DCDC2-20-REAQ 20 (40 μL) 200 μL
PC-DCDC2-20-ORRE 20 (40 μL) 200 μL
PC-DCDC2-20-OROR 20 (40 μL) 200 μL
PC-DCDC2-20-ORGO 20 (40 μL) 200 μL
PC-DCDC2-20-ORAQ 20 (40 μL) 200 μL
PC-DCDC2-20-GORE 20 (40 μL) 200 μL
PC-DCDC2-20-GOOR 20 (40 μL) 200 μL
PC-DCDC2-20-GOGO 20 (40 μL) 200 μL
PC-DCDC2-20-GOGR 20 (40 μL) 200 μL
PC-DCDC2-20-GOAQ 20 (40 μL) 200 μL
PC-DCDC2-20-GRRE 20 (40 μL) 200 μL
PC-DCDC2-20-GROR 20 (40 μL) 200 μL
PC-DCDC2-20-GRGO 20 (40 μL) 200 μL
PC-DCDC2-20-GRGR 20 (40 μL) 200 μL
PC-DCDC2-20-GRAQ 20 (40 μL) 200 μL
PC-DCDC2-20-AQRE 20 (40 μL) 200 μL
PC-DCDC2-20-AQOR 20 (40 μL) 200 μL
PC-DCDC2-20-AQGO 20 (40 μL) 200 μL
PC-DCDC2-20-AQGR 20 (40 μL) 200 μL
PC-DCDC2-20-AQAQ 20 (40 μL) 200 μL

PC Gene Summary

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Pyruvate Carboxylase

Chromosome: CHR11: 66615996 -66725847

Locus: 11q13.2

DCDC2 Gene Summary

This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

Gene Name: Doublecortin Domain Containing 2

Chromosome: CHR6: 24171982 -24383520

Locus: 6p22.3

Gene Diseases

The PC DCDC2 Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.