PC-MX2 Fusion FISH Probe
The PC-MX2 Fusion FISH Probe is used to confirm a fusion of the PC and MX2 genes. The fusion of the PC and MX2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PC-MX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PC-MX2-20-RERE | 20 (40 μL) | 200 μL |
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| PC-MX2-20-REOR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-REGO | 20 (40 μL) | 200 μL |
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| PC-MX2-20-REGR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-REAQ | 20 (40 μL) | 200 μL |
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| PC-MX2-20-ORRE | 20 (40 μL) | 200 μL |
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| PC-MX2-20-OROR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-ORGO | 20 (40 μL) | 200 μL |
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| PC-MX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GORE | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GOOR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GOGO | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GOGR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GRRE | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GROR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GRGO | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GRGR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PC-MX2-20-AQRE | 20 (40 μL) | 200 μL |
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| PC-MX2-20-AQOR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-AQGO | 20 (40 μL) | 200 μL |
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| PC-MX2-20-AQGR | 20 (40 μL) | 200 μL |
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| PC-MX2-20-AQAQ | 20 (40 μL) | 200 μL |
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MX2 Gene Summary
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
Gene Name: MX Dynamin Like GTPase 2
Chromosome: CHR21: 42733949 -42780869
Locus: 21q22.3
PC Gene Summary
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Carboxylase
Chromosome: CHR11: 66615996 -66725847
Locus: 11q13.2
Gene Diseases
The PC MX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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