PCBP1-UTRN Fusion FISH Probe
The PCBP1-UTRN Fusion FISH Probe is used to confirm a fusion of the PCBP1 and UTRN genes. The fusion of the PCBP1 and UTRN genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCBP1-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| PCBP1-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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PCBP1 Gene Summary
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
Gene Name: Poly(rC) Binding Protein 1
Chromosome: CHR2: 70314584 -70316334
Locus: 2p13.3
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The PCBP1 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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