PCBP4-POC1A Fusion FISH Probe
The PCBP4-POC1A Fusion FISH Probe is used to confirm a fusion of the PCBP4 and POC1A genes. The fusion of the PCBP4 and POC1A genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCBP4-POC1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-RERE | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-REOR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-REGO | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-REGR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-REAQ | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-ORRE | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-OROR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-ORGO | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GORE | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GOOR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GOGO | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GOGR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GRRE | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GROR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GRGO | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GRGR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-AQRE | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-AQOR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-AQGO | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-AQGR | 20 (40 μL) | 200 μL |
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| PCBP4-POC1A-20-AQAQ | 20 (40 μL) | 200 μL |
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POC1A Gene Summary
POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome. [provided by RefSeq, Sep 2012]
Gene Name: POC1 Centriolar Protein A
Chromosome: CHR3: 52109248 -52188706
Locus: 3p21.2
PCBP4 Gene Summary
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]
Gene Name: Poly(rC) Binding Protein 4
Chromosome: CHR3: 51991469 -52001482
Locus: 3p21.2
Gene Diseases
The PCBP4 POC1A Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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