PCCA-MBNL2 Fusion FISH Probe
The PCCA-MBNL2 Fusion FISH Probe is used to confirm a fusion of the PCCA and MBNL2 genes. The fusion of the PCCA and MBNL2 genes has been associated with Ovarian Serous Cystadenocarcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCCA-MBNL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-RERE | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-REOR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-REGO | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-REGR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-REAQ | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-ORRE | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-OROR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-ORGO | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GORE | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GOOR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GOGO | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GOGR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GRRE | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GROR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GRGO | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GRGR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-AQRE | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-AQOR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-AQGO | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-AQGR | 20 (40 μL) | 200 μL |
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| PCCA-MBNL2-20-AQAQ | 20 (40 μL) | 200 μL |
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PCCA Gene Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Name: Propionyl-CoA Carboxylase Alpha Subunit
Chromosome: CHR13: 100741268 -101182691
Locus: 13q32.3
MBNL2 Gene Summary
This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. [provided by RefSeq, Mar 2012]
Gene Name: Muscleblind Like Splicing Regulator 2
Chromosome: CHR13: 97874573 -98046374
Locus: 13q32.1
Gene Diseases
The PCCA MBNL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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