PCCA-ZIC2 Fusion FISH Probe
The PCCA-ZIC2 Fusion FISH Probe is used to confirm a fusion of the PCCA and ZIC2 genes. The fusion of the PCCA and ZIC2 genes has been associated with Liver Hepatocellular Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCCA-ZIC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-RERE | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-REOR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-REGO | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-REGR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-REAQ | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-ORRE | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-OROR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-ORGO | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GORE | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GOOR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GOGO | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GOGR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GRRE | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GROR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GRGO | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GRGR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-AQRE | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-AQOR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-AQGO | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-AQGR | 20 (40 μL) | 200 μL |
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| PCCA-ZIC2-20-AQAQ | 20 (40 μL) | 200 μL |
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PCCA Gene Summary
The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Gene Name: Propionyl-CoA Carboxylase Alpha Subunit
Chromosome: CHR13: 100741268 -101182691
Locus: 13q32.3
ZIC2 Gene Summary
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2016]
Gene Name: Zic Family Member 2
Chromosome: CHR13: 100634025 -100639019
Locus: 13q32.3
Gene Diseases
The PCCA ZIC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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