PCDHA11-ANKHD1 Fusion FISH Probe
The PCDHA11-ANKHD1 Fusion FISH Probe is used to confirm a fusion of the PCDHA11 and ANKHD1 genes. The fusion of the PCDHA11 and ANKHD1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCDHA11-ANKHD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-RERE | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-REOR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-REGO | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-REGR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-REAQ | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-ORRE | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-OROR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-ORGO | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GORE | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GOOR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GOGO | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GOGR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GRRE | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GROR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GRGO | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GRGR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-AQRE | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-AQOR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-AQGO | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-AQGR | 20 (40 μL) | 200 μL |
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| PCDHA11-ANKHD1-20-AQAQ | 20 (40 μL) | 200 μL |
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ANKHD1 Gene Summary
This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Sep 2010]
Gene Name: Ankyrin Repeat And KH Domain Containing 1
Chromosome: CHR5: 139781398 -139919441
Locus: 5q31.3
PCDHA11 Gene Summary
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
Gene Name: Protocadherin Alpha 11
Chromosome: CHR5: 140247830 -140391929
Locus: 5q31.3
Gene Diseases
The PCDHA11 ANKHD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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