PCDHGB4-TYK2 Fusion FISH Probe
The PCDHGB4-TYK2 Fusion FISH Probe is used to confirm a fusion of the PCDHGB4 and TYK2 genes. The fusion of the PCDHGB4 and TYK2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCDHGB4-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| PCDHGB4-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
PCDHGB4 Gene Summary
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Name: Protocadherin Gamma Subfamily B, 4
Chromosome: CHR5: 140767451 -140892546
Locus: 5q31.3
Gene Diseases
The PCDHGB4 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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