PCM1-NRG1 Fusion FISH Probe
The PCM1-NRG1 Fusion FISH Probe is used to confirm a fusion of the PCM1 and NRG1 genes. The fusion of the PCM1 and NRG1 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCM1-NRG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-RERE | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-REOR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-REGO | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-REGR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-REAQ | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-ORRE | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-OROR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-ORGO | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GORE | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GOOR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GOGO | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GOGR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GRRE | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GROR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GRGO | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GRGR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-AQRE | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-AQOR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-AQGO | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-AQGR | 20 (40 μL) | 200 μL |
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| PCM1-NRG1-20-AQAQ | 20 (40 μL) | 200 μL |
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NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
PCM1 Gene Summary
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Gene Name: Pericentriolar Material 1
Chromosome: CHR8: 17780365 -17887457
Locus: 8p22
Gene Diseases
The PCM1 NRG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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