PCSK5-OSTF1 Fusion FISH Probe
The PCSK5-OSTF1 Fusion FISH Probe is used to confirm a fusion of the PCSK5 and OSTF1 genes. The fusion of the PCSK5 and OSTF1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PCSK5-OSTF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-RERE | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-REOR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-REGO | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-REGR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-REAQ | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-ORRE | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-OROR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-ORGO | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GORE | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GOOR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GOGO | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GOGR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GRRE | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GROR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GRGO | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GRGR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-AQRE | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-AQOR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-AQGO | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-AQGR | 20 (40 μL) | 200 μL |
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| PCSK5-OSTF1-20-AQAQ | 20 (40 μL) | 200 μL |
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PCSK5 Gene Summary
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
Gene Name: Proprotein Convertase Subtilisin/kexin Type 5
Chromosome: CHR9: 78505559 -78977255
Locus: 9q21.13
OSTF1 Gene Summary
Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]
Gene Name: Osteoclast Stimulating Factor 1
Chromosome: CHR9: 77703397 -77762114
Locus: 9q21.13
Gene Diseases
The PCSK5 OSTF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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