PDE10A-DDX23 Fusion FISH Probe
The PDE10A-DDX23 Fusion FISH Probe is used to confirm a fusion of the PDE10A and DDX23 genes. The fusion of the PDE10A and DDX23 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE10A-DDX23-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-RERE | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-REOR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-REGO | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-REGR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-OROR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GORE | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GROR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE10A-DDX23-20-AQAQ | 20 (40 μL) | 200 μL |
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DDX23 Gene Summary
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: DEAD-box Helicase 23
Chromosome: CHR12: 49223538 -49245957
Locus: 12q13.12
PDE10A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Phosphodiesterase 10A
Chromosome: CHR6: 165740777 -166075584
Locus: 6q27
Gene Diseases
The PDE10A DDX23 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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