PDE10A-PSMB1 Fusion FISH Probe
The PDE10A-PSMB1 Fusion FISH Probe is used to confirm a fusion of the PDE10A and PSMB1 genes. The fusion of the PDE10A and PSMB1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE10A-PSMB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-RERE | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-REOR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-REGO | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-REGR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-OROR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GORE | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GROR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE10A-PSMB1-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMB1 Gene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]
Gene Name: Proteasome Subunit Beta 1
Chromosome: CHR6: 170844203 -170862417
Locus: 6q27
PDE10A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Phosphodiesterase 10A
Chromosome: CHR6: 165740777 -166075584
Locus: 6q27
Gene Diseases
The PDE10A PSMB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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