PDE1A-PPP1R1C Fusion FISH Probe
The PDE1A-PPP1R1C Fusion FISH Probe is used to confirm a fusion of the PDE1A and PPP1R1C genes. The fusion of the PDE1A and PPP1R1C genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE1A-PPP1R1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-RERE | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-REOR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-REGO | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-REGR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-OROR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GORE | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GROR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE1A-PPP1R1C-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE1A Gene Summary
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
Gene Name: Phosphodiesterase 1A
Chromosome: CHR2: 183007182 -183387253
Locus: 2q32.1
PPP1R1C Gene Summary
Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]
Gene Name: Protein Phosphatase 1 Regulatory Inhibitor Subunit 1C
Chromosome: CHR2: 182850550 -182982419
Locus: 2q31.3-q32.1
Gene Diseases
The PDE1A PPP1R1C Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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