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PDE3A-CCT2 Fusion FISH Probe

The PDE3A-CCT2 Fusion FISH Probe is used to confirm a fusion of the PDE3A and CCT2 genes. The fusion of the PDE3A and CCT2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PDE3A-CCT2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PDE3A-CCT2-20-RERE 20 (40 μL) 200 μL
PDE3A-CCT2-20-REOR 20 (40 μL) 200 μL
PDE3A-CCT2-20-REGO 20 (40 μL) 200 μL
PDE3A-CCT2-20-REGR 20 (40 μL) 200 μL
PDE3A-CCT2-20-REAQ 20 (40 μL) 200 μL
PDE3A-CCT2-20-ORRE 20 (40 μL) 200 μL
PDE3A-CCT2-20-OROR 20 (40 μL) 200 μL
PDE3A-CCT2-20-ORGO 20 (40 μL) 200 μL
PDE3A-CCT2-20-ORAQ 20 (40 μL) 200 μL
PDE3A-CCT2-20-GORE 20 (40 μL) 200 μL
PDE3A-CCT2-20-GOOR 20 (40 μL) 200 μL
PDE3A-CCT2-20-GOGO 20 (40 μL) 200 μL
PDE3A-CCT2-20-GOGR 20 (40 μL) 200 μL
PDE3A-CCT2-20-GOAQ 20 (40 μL) 200 μL
PDE3A-CCT2-20-GRRE 20 (40 μL) 200 μL
PDE3A-CCT2-20-GROR 20 (40 μL) 200 μL
PDE3A-CCT2-20-GRGO 20 (40 μL) 200 μL
PDE3A-CCT2-20-GRGR 20 (40 μL) 200 μL
PDE3A-CCT2-20-GRAQ 20 (40 μL) 200 μL
PDE3A-CCT2-20-AQRE 20 (40 μL) 200 μL
PDE3A-CCT2-20-AQOR 20 (40 μL) 200 μL
PDE3A-CCT2-20-AQGO 20 (40 μL) 200 μL
PDE3A-CCT2-20-AQGR 20 (40 μL) 200 μL
PDE3A-CCT2-20-AQAQ 20 (40 μL) 200 μL

PDE3A Gene Summary

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Gene Name: Phosphodiesterase 3A

Chromosome: CHR12: 20522196 -20833881

Locus: 12p12.2

CCT2 Gene Summary

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Gene Name: Chaperonin Containing TCP1 Subunit 2

Chromosome: CHR12: 69979207 -69995357

Locus: 12q15

Gene Diseases

The PDE3A CCT2 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.