PDE7A-NRG1 Fusion FISH Probe
The PDE7A-NRG1 Fusion FISH Probe is used to confirm a fusion of the PDE7A and NRG1 genes. The fusion of the PDE7A and NRG1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PDE7A-NRG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-RERE | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-REOR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-REGO | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-REGR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-REAQ | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-ORRE | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-OROR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-ORGO | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GORE | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GOOR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GOGO | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GOGR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GRRE | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GROR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GRGO | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GRGR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-AQRE | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-AQOR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-AQGO | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-AQGR | 20 (40 μL) | 200 μL |
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| PDE7A-NRG1-20-AQAQ | 20 (40 μL) | 200 μL |
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NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
PDE7A Gene Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Gene Name: Phosphodiesterase 7A
Chromosome: CHR8: 66626568 -66753969
Locus: 8q13.1
Gene Diseases
The PDE7A NRG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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