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PDK3-NAV3 Fusion FISH Probe

The PDK3-NAV3 Fusion FISH Probe is used to confirm a fusion of the PDK3 and NAV3 genes. The fusion of the PDK3 and NAV3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PDK3-NAV3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PDK3-NAV3-20-RERE 20 (40 μL) 200 μL
PDK3-NAV3-20-REOR 20 (40 μL) 200 μL
PDK3-NAV3-20-REGO 20 (40 μL) 200 μL
PDK3-NAV3-20-REGR 20 (40 μL) 200 μL
PDK3-NAV3-20-REAQ 20 (40 μL) 200 μL
PDK3-NAV3-20-ORRE 20 (40 μL) 200 μL
PDK3-NAV3-20-OROR 20 (40 μL) 200 μL
PDK3-NAV3-20-ORGO 20 (40 μL) 200 μL
PDK3-NAV3-20-ORAQ 20 (40 μL) 200 μL
PDK3-NAV3-20-GORE 20 (40 μL) 200 μL
PDK3-NAV3-20-GOOR 20 (40 μL) 200 μL
PDK3-NAV3-20-GOGO 20 (40 μL) 200 μL
PDK3-NAV3-20-GOGR 20 (40 μL) 200 μL
PDK3-NAV3-20-GOAQ 20 (40 μL) 200 μL
PDK3-NAV3-20-GRRE 20 (40 μL) 200 μL
PDK3-NAV3-20-GROR 20 (40 μL) 200 μL
PDK3-NAV3-20-GRGO 20 (40 μL) 200 μL
PDK3-NAV3-20-GRGR 20 (40 μL) 200 μL
PDK3-NAV3-20-GRAQ 20 (40 μL) 200 μL
PDK3-NAV3-20-AQRE 20 (40 μL) 200 μL
PDK3-NAV3-20-AQOR 20 (40 μL) 200 μL
PDK3-NAV3-20-AQGO 20 (40 μL) 200 μL
PDK3-NAV3-20-AQGR 20 (40 μL) 200 μL
PDK3-NAV3-20-AQAQ 20 (40 μL) 200 μL

PDK3 Gene Summary

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Gene Name: Pyruvate Dehydrogenase Kinase 3

Chromosome: CHRX: 24483343 -24568583

Locus: Xp22.11

NAV3 Gene Summary

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]

Gene Name: Neuron Navigator 3

Chromosome: CHR12: 78225068 -78606790

Locus: 12q21.2

Gene Diseases

The PDK3 NAV3 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.