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PDS5B-ATP8A2 Fusion FISH Probe

The PDS5B-ATP8A2 Fusion FISH Probe is used to confirm a fusion of the PDS5B and ATP8A2 genes. The fusion of the PDS5B and ATP8A2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PDS5B-ATP8A2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-RERE 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-REOR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-REGO 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-REGR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-REAQ 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-ORRE 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-OROR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-ORGO 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-ORAQ 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GORE 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GOOR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GOGO 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GOGR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GOAQ 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GRRE 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GROR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GRGO 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GRGR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-GRAQ 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-AQRE 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-AQOR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-AQGO 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-AQGR 20 (40 μL) 200 μL
PDS5B-ATP8A2-20-AQAQ 20 (40 μL) 200 μL

PDS5B Gene Summary

This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]

Gene Name: PDS5 Cohesin Associated Factor B

Chromosome: CHR13: 33160563 -33352158

Locus: 13q13.1

ATP8A2 Gene Summary

The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with a syndrome (CAMRQ4) characterized by cerebellar ataxia and cognitive disabilities. In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

Gene Name: ATPase Phospholipid Transporting 8A2

Chromosome: CHR13: 25946208 -26595420

Locus: 13q12.13

Gene Diseases

The PDS5B ATP8A2 Fusion has been associated with the following diseases:

Disease Name
Skin Cutaneous Melanoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.