PDS5B-TBC1D4 Fusion FISH Probe
The PDS5B-TBC1D4 Fusion FISH Probe is used to confirm a fusion of the PDS5B and TBC1D4 genes. The fusion of the PDS5B and TBC1D4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PDS5B-TBC1D4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PDS5B-TBC1D4-20-AQAQ | 20 (40 μL) | 200 μL |
|
TBC1D4 Gene Summary
This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Name: TBC1 Domain Family Member 4
Chromosome: CHR13: 75858808 -76056250
Locus: 13q22.2
PDS5B Gene Summary
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Gene Name: PDS5 Cohesin Associated Factor B
Chromosome: CHR13: 33160563 -33352158
Locus: 13q13.1
Gene Diseases
The PDS5B TBC1D4 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|