PER2-HDAC4 Fusion FISH Probe
The PER2-HDAC4 Fusion FISH Probe is used to confirm a fusion of the PER2 and HDAC4 genes. The fusion of the PER2 and HDAC4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PER2-HDAC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-RERE | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-REOR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-REGO | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-REGR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-REAQ | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-ORRE | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-OROR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-ORGO | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GORE | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GOOR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GOGO | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GOGR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GRRE | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GROR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GRGO | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GRGR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-AQRE | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-AQOR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-AQGO | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-AQGR | 20 (40 μL) | 200 μL |
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| PER2-HDAC4-20-AQAQ | 20 (40 μL) | 200 μL |
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PER2 Gene Summary
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Gene Name: Period Circadian Regulator 2
Chromosome: CHR2: 239152678 -239197207
Locus: 2q37.3
HDAC4 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 4
Chromosome: CHR2: 239969863 -240322643
Locus: 2q37.3
Gene Diseases
The PER2 HDAC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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