PFKFB4-MYRIP Fusion FISH Probe
The PFKFB4-MYRIP Fusion FISH Probe is used to confirm a fusion of the PFKFB4 and MYRIP genes. The fusion of the PFKFB4 and MYRIP genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PFKFB4-MYRIP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-RERE | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-REOR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-REGO | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-REGR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-REAQ | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-ORRE | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-OROR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-ORGO | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-ORAQ | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GORE | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GOOR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GOGO | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GOGR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GOAQ | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GRRE | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GROR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GRGO | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GRGR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-GRAQ | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-AQRE | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-AQOR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-AQGO | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-AQGR | 20 (40 μL) | 200 μL |
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| PFKFB4-MYRIP-20-AQAQ | 20 (40 μL) | 200 μL |
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PFKFB4 Gene Summary
The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Chromosome: CHR3: 48555116 -48594227
Locus: 3p21.31
MYRIP Gene Summary
The Myosin VIIA And Rab Interacting Protein (MYRIP) gene is located on chr3 :39851302-40301811 at 3p22.1.
Gene Name: Myosin VIIA And Rab Interacting Protein
Chromosome: CHR3: 39851302 -40301811
Locus: 3p22.1
Gene Diseases
The PFKFB4 MYRIP Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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