PICALM-ME3 Fusion FISH Probe
The PICALM-ME3 Fusion FISH Probe is used to confirm a fusion of the PICALM and ME3 genes. The fusion of the PICALM and ME3 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PICALM-ME3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-RERE | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-REOR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-REGO | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-REGR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-REAQ | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-ORRE | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-OROR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-ORGO | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GORE | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GOOR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GOGO | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GOGR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GRRE | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GROR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GRGO | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GRGR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-AQRE | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-AQOR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-AQGO | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-AQGR | 20 (40 μL) | 200 μL |
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| PICALM-ME3-20-AQAQ | 20 (40 μL) | 200 μL |
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PICALM Gene Summary
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Phosphatidylinositol Binding Clathrin Assembly Protein
Chromosome: CHR11: 85668213 -85780923
Locus: 11q14.2
ME3 Gene Summary
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Malic Enzyme 3
Chromosome: CHR11: 86152149 -86383678
Locus: 11q14.2
Gene Diseases
The PICALM ME3 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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