PICK1-GCAT Fusion FISH Probe
The PICK1-GCAT Fusion FISH Probe is used to confirm a fusion of the PICK1 and GCAT genes. The fusion of the PICK1 and GCAT genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PICK1-GCAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-RERE | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-REOR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-REGO | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-REGR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-REAQ | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-ORRE | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-OROR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-ORGO | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GORE | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GOOR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GOGO | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GOGR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GRRE | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GROR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GRGO | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GRGR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-AQRE | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-AQOR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-AQGO | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-AQGR | 20 (40 μL) | 200 μL |
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| PICK1-GCAT-20-AQAQ | 20 (40 μL) | 200 μL |
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PICK1 Gene Summary
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Protein Interacting With PRKCA 1
Chromosome: CHR22: 38453261 -38471708
Locus: 22q13.1
GCAT Gene Summary
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
Gene Name: Glycine C-acetyltransferase
Chromosome: CHR22: 38203911 -38213183
Locus: 22q13.1
Gene Diseases
The PICK1 GCAT Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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