PIK3CB-SEMA5B Fusion FISH Probe
The PIK3CB-SEMA5B Fusion FISH Probe is used to confirm a fusion of the PIK3CB and SEMA5B genes. The fusion of the PIK3CB and SEMA5B genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIK3CB-SEMA5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-RERE | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-REOR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-REGO | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-REGR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-REAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-ORRE | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-OROR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-ORGO | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GORE | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GOOR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GOGO | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GOGR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GRRE | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GROR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GRGO | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GRGR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-AQRE | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-AQOR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-AQGO | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-AQGR | 20 (40 μL) | 200 μL |
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| PIK3CB-SEMA5B-20-AQAQ | 20 (40 μL) | 200 μL |
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PIK3CB Gene Summary
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta
Chromosome: CHR3: 138374230 -138478185
Locus: 3q22.3
SEMA5B Gene Summary
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Semaphorin 5B
Chromosome: CHR3: 122628042 -122746576
Locus: 3q21.1
Gene Diseases
The PIK3CB SEMA5B Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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