PIN1-PPP2R3C Fusion FISH Probe
The PIN1-PPP2R3C Fusion FISH Probe is used to confirm a fusion of the PIN1 and PPP2R3C genes. The fusion of the PIN1 and PPP2R3C genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PIN1-PPP2R3C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-RERE | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-REOR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-REGO | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-REGR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-REAQ | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-ORRE | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-OROR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-ORGO | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-ORAQ | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GORE | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GOOR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GOGO | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GOGR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GOAQ | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GRRE | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GROR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GRGO | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GRGR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-GRAQ | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-AQRE | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-AQOR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-AQGO | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-AQGR | 20 (40 μL) | 200 μL |
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| PIN1-PPP2R3C-20-AQAQ | 20 (40 μL) | 200 μL |
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PIN1 Gene Summary
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Gene Name: Peptidylprolyl Cis/trans Isomerase, NIMA-interacting 1
Chromosome: CHR19: 9945882 -9960365
Locus: 19p13.2
PPP2R3C Gene Summary
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Gene Name: Protein Phosphatase 2 Regulatory Subunit B''gamma
Chromosome: CHR14: 35554677 -35591519
Locus: 14q13.2
Gene Diseases
The PIN1 PPP2R3C Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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