PKHD1-RCAN2 Fusion FISH Probe
The PKHD1-RCAN2 Fusion FISH Probe is used to confirm a fusion of the PKHD1 and RCAN2 genes. The fusion of the PKHD1 and RCAN2 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PKHD1-RCAN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-RERE | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-REOR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-REGO | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-REGR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-REAQ | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-ORRE | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-OROR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-ORGO | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GORE | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GOOR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GOGO | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GOGR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GRRE | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GROR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GRGO | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GRGR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-AQRE | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-AQOR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-AQGO | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-AQGR | 20 (40 μL) | 200 μL |
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| PKHD1-RCAN2-20-AQAQ | 20 (40 μL) | 200 μL |
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PKHD1 Gene Summary
The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1. [provided by RefSeq, Jul 2008]
Gene Name: PKHD1, Fibrocystin/polyductin
Chromosome: CHR6: 51480144 -51952423
Locus: 6p12.3-p12.2
RCAN2 Gene Summary
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Regulator Of Calcineurin 2
Chromosome: CHR6: 46188468 -46293531
Locus: 6p12.3
Gene Diseases
The PKHD1 RCAN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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