PKMYT1-CLDN6 Fusion FISH Probe
The PKMYT1-CLDN6 Fusion FISH Probe is used to confirm a fusion of the PKMYT1 and CLDN6 genes. The fusion of the PKMYT1 and CLDN6 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PKMYT1-CLDN6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-RERE | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-REOR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-REGO | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-REGR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-REAQ | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-ORRE | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-OROR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-ORGO | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-ORAQ | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GORE | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GOOR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GOGO | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GOGR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GOAQ | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GRRE | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GROR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GRGO | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GRGR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-GRAQ | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-AQRE | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-AQOR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-AQGO | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-AQGR | 20 (40 μL) | 200 μL |
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| PKMYT1-CLDN6-20-AQAQ | 20 (40 μL) | 200 μL |
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CLDN6 Gene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Gene Name: Claudin 6
Chromosome: CHR16: 3064712 -3068188
Locus: 16p13.3
PKMYT1 Gene Summary
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Name: Protein Kinase, Membrane Associated Tyrosine/threonine 1
Chromosome: CHR16: 3022791 -3030540
Locus: 16p13.3
Gene Diseases
The PKMYT1 CLDN6 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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