PLA2G2A-CLCN3 Fusion FISH Probe
The PLA2G2A-CLCN3 Fusion FISH Probe is used to confirm a fusion of the PLA2G2A and CLCN3 genes. The fusion of the PLA2G2A and CLCN3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLA2G2A-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
PLA2G2A Gene Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Name: Phospholipase A2 Group IIA
Chromosome: CHR1: 20301923 -20306932
Locus: 1p36.13
Gene Diseases
The PLA2G2A CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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