PLA2G2A-PLAT Fusion FISH Probe
The PLA2G2A-PLAT Fusion FISH Probe is used to confirm a fusion of the PLA2G2A and PLAT genes. The fusion of the PLA2G2A and PLAT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLA2G2A-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| PLA2G2A-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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PLA2G2A Gene Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Name: Phospholipase A2 Group IIA
Chromosome: CHR1: 20301923 -20306932
Locus: 1p36.13
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The PLA2G2A PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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