PLCG1-TAF4 Fusion FISH Probe
The PLCG1-TAF4 Fusion FISH Probe is used to confirm a fusion of the PLCG1 and TAF4 genes. The fusion of the PLCG1 and TAF4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCG1-TAF4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-RERE | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-REOR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-REGO | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-REGR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-OROR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GORE | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GROR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCG1-TAF4-20-AQAQ | 20 (40 μL) | 200 μL |
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PLCG1 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phospholipase C Gamma 1
Chromosome: CHR20: 39766160 -39804357
Locus: 20q12
TAF4 Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008]
Gene Name: TATA-box Binding Protein Associated Factor 4
Chromosome: CHR20: 60549853 -60640866
Locus: 20q13.33
Gene Diseases
The PLCG1 TAF4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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