PLCG2-WWOX Fusion FISH Probe
The PLCG2-WWOX Fusion FISH Probe is used to confirm a fusion of the PLCG2 and WWOX genes. The fusion of the PLCG2 and WWOX genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLCG2-WWOX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-RERE | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-REOR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-REGO | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-REGR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-REAQ | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-ORRE | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-OROR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-ORGO | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GORE | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GOOR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GOGO | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GOGR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GRRE | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GROR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GRGO | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GRGR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-AQRE | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-AQOR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-AQGO | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-AQGR | 20 (40 μL) | 200 μL |
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| PLCG2-WWOX-20-AQAQ | 20 (40 μL) | 200 μL |
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PLCG2 Gene Summary
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
Gene Name: Phospholipase C Gamma 2
Chromosome: CHR16: 81812898 -81991899
Locus: 16q23.3
WWOX Gene Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: WW Domain Containing Oxidoreductase
Chromosome: CHR16: 78133326 -79246564
Locus: 16q23.1-q23.2
Gene Diseases
The PLCG2 WWOX Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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