PLEKHB1-PACS1 Fusion FISH Probe
The PLEKHB1-PACS1 Fusion FISH Probe is used to confirm a fusion of the PLEKHB1 and PACS1 genes. The fusion of the PLEKHB1 and PACS1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLEKHB1-PACS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-RERE | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-REOR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-REGO | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-REGR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-OROR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GORE | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GROR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLEKHB1-PACS1-20-AQAQ | 20 (40 μL) | 200 μL |
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PACS1 Gene Summary
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Gene Name: Phosphofurin Acidic Cluster Sorting Protein 1
Chromosome: CHR11: 65837823 -66012213
Locus: 11q13.1-q13.2
PLEKHB1 Gene Summary
The Pleckstrin Homology Domain Containing B1 (PLEKHB1) gene is located on chr11 :73357222-73373864 at 11q13.4.
Gene Name: Pleckstrin Homology Domain Containing B1
Chromosome: CHR11: 73357222 -73373864
Locus: 11q13.4
Gene Diseases
The PLEKHB1 PACS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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