PLEKHG5-TNFRSF8 Fusion FISH Probe
The PLEKHG5-TNFRSF8 Fusion FISH Probe is used to confirm a fusion of the PLEKHG5 and TNFRSF8 genes. The fusion of the PLEKHG5 and TNFRSF8 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLEKHG5-TNFRSF8-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-RERE | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-REOR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-REGO | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-REGR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-REAQ | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-ORRE | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-OROR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-ORGO | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GORE | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GOOR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GOGO | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GOGR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GRRE | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GROR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GRGO | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GRGR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-AQRE | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-AQOR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-AQGO | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-AQGR | 20 (40 μL) | 200 μL |
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| PLEKHG5-TNFRSF8-20-AQAQ | 20 (40 μL) | 200 μL |
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TNFRSF8 Gene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: TNF Receptor Superfamily Member 8
Chromosome: CHR1: 12123433 -12204264
Locus: 1p36.22
PLEKHG5 Gene Summary
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Name: Pleckstrin Homology And RhoGEF Domain Containing G5
Chromosome: CHR1: 6526151 -6580069
Locus: 1p36.31
Gene Diseases
The PLEKHG5 TNFRSF8 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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