PLP1-SGK1 Fusion FISH Probe
The PLP1-SGK1 Fusion FISH Probe is used to confirm a fusion of the PLP1 and SGK1 genes. The fusion of the PLP1 and SGK1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PLP1-SGK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-RERE | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-REOR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-REGO | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-REGR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-REAQ | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-ORRE | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-OROR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-ORGO | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GORE | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GOOR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GOGO | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GOGR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GRRE | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GROR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GRGO | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GRGR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-AQRE | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-AQOR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-AQGO | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-AQGR | 20 (40 μL) | 200 μL |
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| PLP1-SGK1-20-AQAQ | 20 (40 μL) | 200 μL |
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PLP1 Gene Summary
This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
Gene Name: Proteolipid Protein 1
Chromosome: CHRX: 103031438 -103047547
Locus: Xq22.2
SGK1 Gene Summary
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Gene Name: Serum/glucocorticoid Regulated Kinase 1
Chromosome: CHR6: 134490383 -134639196
Locus: 6q23.2
Gene Diseases
The PLP1 SGK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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