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PLXNC1-TXNRD1 Fusion FISH Probe

The PLXNC1-TXNRD1 Fusion FISH Probe is used to confirm a fusion of the PLXNC1 and TXNRD1 genes. The fusion of the PLXNC1 and TXNRD1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PLXNC1-TXNRD1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-RERE 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-REOR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-REGO 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-REGR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-REAQ 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-ORRE 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-OROR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-ORGO 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-ORAQ 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GORE 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GOOR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GOGO 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GOGR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GOAQ 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GRRE 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GROR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GRGO 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GRGR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-GRAQ 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-AQRE 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-AQOR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-AQGO 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-AQGR 20 (40 μL) 200 μL
PLXNC1-TXNRD1-20-AQAQ 20 (40 μL) 200 μL

TXNRD1 Gene Summary

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]

Gene Name: Thioredoxin Reductase 1

Chromosome: CHR12: 104609558 -104744062

Locus: 12q23.3

PLXNC1 Gene Summary

This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

Gene Name: Plexin C1

Chromosome: CHR12: 94542498 -94701451

Locus: 12q22

Gene Diseases

The PLXNC1 TXNRD1 Fusion has been associated with the following diseases:

Disease Name
Sarcoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.