PMEPA1-ARFGEF2 Fusion FISH Probe
The PMEPA1-ARFGEF2 Fusion FISH Probe is used to confirm a fusion of the PMEPA1 and ARFGEF2 genes. The fusion of the PMEPA1 and ARFGEF2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PMEPA1-ARFGEF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-RERE | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-REOR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-REGO | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-REGR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-REAQ | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-ORRE | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-OROR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-ORGO | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GORE | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GOOR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GOGO | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GOGR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GRRE | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GROR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GRGO | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GRGR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-AQRE | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-AQOR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-AQGO | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-AQGR | 20 (40 μL) | 200 μL |
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| PMEPA1-ARFGEF2-20-AQAQ | 20 (40 μL) | 200 μL |
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ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
PMEPA1 Gene Summary
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Prostate Transmembrane Protein, Androgen Induced 1
Chromosome: CHR20: 56223451 -56286541
Locus: 20q13.31
Gene Diseases
The PMEPA1 ARFGEF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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