PML-POLN Fusion FISH Probe
The PML-POLN Fusion FISH Probe is used to confirm a fusion of the PML and POLN genes. The fusion of the PML and POLN genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PML-POLN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PML-POLN-20-RERE | 20 (40 μL) | 200 μL |
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| PML-POLN-20-REOR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-REGO | 20 (40 μL) | 200 μL |
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| PML-POLN-20-REGR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-REAQ | 20 (40 μL) | 200 μL |
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| PML-POLN-20-ORRE | 20 (40 μL) | 200 μL |
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| PML-POLN-20-OROR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-ORGO | 20 (40 μL) | 200 μL |
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| PML-POLN-20-ORAQ | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GORE | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GOOR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GOGO | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GOGR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GOAQ | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GRRE | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GROR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GRGO | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GRGR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-GRAQ | 20 (40 μL) | 200 μL |
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| PML-POLN-20-AQRE | 20 (40 μL) | 200 μL |
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| PML-POLN-20-AQOR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-AQGO | 20 (40 μL) | 200 μL |
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| PML-POLN-20-AQGR | 20 (40 μL) | 200 μL |
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| PML-POLN-20-AQAQ | 20 (40 μL) | 200 μL |
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PML Gene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Promyelocytic Leukemia
Chromosome: CHR15: 74287013 -74340155
Locus: 15q24.1
POLN Gene Summary
This gene encodes a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit. [provided by RefSeq, Dec 2014]
Gene Name: DNA Polymerase Nu
Chromosome: CHR4: 2073644 -2230958
Locus: 4p16.3
Gene Diseases
The PML POLN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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