PMVK-PYGO2 Fusion FISH Probe
The PMVK-PYGO2 Fusion FISH Probe is used to confirm a fusion of the PMVK and PYGO2 genes. The fusion of the PMVK and PYGO2 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PMVK-PYGO2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-RERE | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-REOR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-REGO | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-REGR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-REAQ | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-ORRE | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-OROR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-ORGO | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GORE | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GOOR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GOGO | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GOGR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GRRE | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GROR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GRGO | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GRGR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-AQRE | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-AQOR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-AQGO | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-AQGR | 20 (40 μL) | 200 μL |
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| PMVK-PYGO2-20-AQAQ | 20 (40 μL) | 200 μL |
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PMVK Gene Summary
This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Name: Phosphomevalonate Kinase
Chromosome: CHR1: 154897207 -154909484
Locus: 1q21.3
PYGO2 Gene Summary
The Pygopus Family PHD Finger 2 (PYGO2) gene is located on chr1 :154929501-154934258 at 1q21.3.
Gene Name: Pygopus Family PHD Finger 2
Chromosome: CHR1: 154929501 -154934258
Locus: 1q21.3
Gene Diseases
The PMVK PYGO2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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