POGZ-GBA Fusion FISH Probe
The POGZ-GBA Fusion FISH Probe is used to confirm a fusion of the POGZ and GBA genes. The fusion of the POGZ and GBA genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POGZ-GBA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-RERE | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-REOR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-REGO | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-REGR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-REAQ | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-ORRE | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-OROR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-ORGO | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-ORAQ | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GORE | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GOOR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GOGO | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GOGR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GOAQ | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GRRE | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GROR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GRGO | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GRGR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-GRAQ | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-AQRE | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-AQOR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-AQGO | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-AQGR | 20 (40 μL) | 200 μL |
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| POGZ-GBA-20-AQAQ | 20 (40 μL) | 200 μL |
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GBA Gene Summary
This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Gene Name: Glucosylceramidase Beta
Chromosome: CHR1: 155204238 -155214653
Locus: 1q22
POGZ Gene Summary
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Gene Name: Pogo Transposable Element Derived With ZNF Domain
Chromosome: CHR1: 151375199 -151431941
Locus: 1q21.3
Gene Diseases
The POGZ GBA Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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