POLB-IKBKB Fusion FISH Probe
The POLB-IKBKB Fusion FISH Probe is used to confirm a fusion of the POLB and IKBKB genes. The fusion of the POLB and IKBKB genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLB-IKBKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-RERE | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-REOR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-REGO | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-REGR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-REAQ | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-ORRE | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-OROR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-ORGO | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GORE | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GOOR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GOGO | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GOGR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GRRE | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GROR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GRGO | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GRGR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-AQRE | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-AQOR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-AQGO | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-AQGR | 20 (40 μL) | 200 μL |
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| POLB-IKBKB-20-AQAQ | 20 (40 μL) | 200 μL |
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IKBKB Gene Summary
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta
Chromosome: CHR8: 42128819 -42190171
Locus: 8p11.21
POLB Gene Summary
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Gene Name: DNA Polymerase Beta
Chromosome: CHR8: 42195972 -42229331
Locus: 8p11.21
Gene Diseases
The POLB IKBKB Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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