POLD3-ENC1 Fusion FISH Probe
The POLD3-ENC1 Fusion FISH Probe is used to confirm a fusion of the POLD3 and ENC1 genes. The fusion of the POLD3 and ENC1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLD3-ENC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-RERE | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-REOR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-REGO | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-REGR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-REAQ | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-ORRE | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-OROR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-ORGO | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GORE | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GOOR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GOGO | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GOGR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GRRE | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GROR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GRGO | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GRGR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-AQRE | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-AQOR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-AQGO | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-AQGR | 20 (40 μL) | 200 μL |
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| POLD3-ENC1-20-AQAQ | 20 (40 μL) | 200 μL |
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ENC1 Gene Summary
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Ectodermal-neural Cortex 1
Chromosome: CHR5: 73923233 -73937249
Locus: 5q13.3
POLD3 Gene Summary
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: DNA Polymerase Delta 3, Accessory Subunit
Chromosome: CHR11: 74303628 -74353765
Locus: 11q13.4
Gene Diseases
The POLD3 ENC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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