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POLD3-PPME1 Fusion FISH Probe

The POLD3-PPME1 Fusion FISH Probe is used to confirm a fusion of the POLD3 and PPME1 genes. The fusion of the POLD3 and PPME1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
POLD3-PPME1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
POLD3-PPME1-20-RERE 20 (40 μL) 200 μL
POLD3-PPME1-20-REOR 20 (40 μL) 200 μL
POLD3-PPME1-20-REGO 20 (40 μL) 200 μL
POLD3-PPME1-20-REGR 20 (40 μL) 200 μL
POLD3-PPME1-20-REAQ 20 (40 μL) 200 μL
POLD3-PPME1-20-ORRE 20 (40 μL) 200 μL
POLD3-PPME1-20-OROR 20 (40 μL) 200 μL
POLD3-PPME1-20-ORGO 20 (40 μL) 200 μL
POLD3-PPME1-20-ORAQ 20 (40 μL) 200 μL
POLD3-PPME1-20-GORE 20 (40 μL) 200 μL
POLD3-PPME1-20-GOOR 20 (40 μL) 200 μL
POLD3-PPME1-20-GOGO 20 (40 μL) 200 μL
POLD3-PPME1-20-GOGR 20 (40 μL) 200 μL
POLD3-PPME1-20-GOAQ 20 (40 μL) 200 μL
POLD3-PPME1-20-GRRE 20 (40 μL) 200 μL
POLD3-PPME1-20-GROR 20 (40 μL) 200 μL
POLD3-PPME1-20-GRGO 20 (40 μL) 200 μL
POLD3-PPME1-20-GRGR 20 (40 μL) 200 μL
POLD3-PPME1-20-GRAQ 20 (40 μL) 200 μL
POLD3-PPME1-20-AQRE 20 (40 μL) 200 μL
POLD3-PPME1-20-AQOR 20 (40 μL) 200 μL
POLD3-PPME1-20-AQGO 20 (40 μL) 200 μL
POLD3-PPME1-20-AQGR 20 (40 μL) 200 μL
POLD3-PPME1-20-AQAQ 20 (40 μL) 200 μL

POLD3 Gene Summary

This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

Gene Name: DNA Polymerase Delta 3, Accessory Subunit

Chromosome: CHR11: 74303628 -74353765

Locus: 11q13.4

PPME1 Gene Summary

This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Gene Name: Protein Phosphatase Methylesterase 1

Chromosome: CHR11: 73882367 -73965748

Locus: 11q13.4

Gene Diseases

The POLD3 PPME1 Fusion has been associated with the following diseases:

Disease Name
Uterine Corpus Endometrial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.