POLK-HSD17B4 Fusion FISH Probe
The POLK-HSD17B4 Fusion FISH Probe is used to confirm a fusion of the POLK and HSD17B4 genes. The fusion of the POLK and HSD17B4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLK-HSD17B4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-RERE | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-REOR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-REGO | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-REGR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-REAQ | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-ORRE | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-OROR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-ORGO | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GORE | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GOOR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GOGO | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GOGR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GRRE | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GROR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GRGO | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GRGR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-AQRE | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-AQOR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-AQGO | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-AQGR | 20 (40 μL) | 200 μL |
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| POLK-HSD17B4-20-AQAQ | 20 (40 μL) | 200 μL |
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HSD17B4 Gene Summary
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Name: Hydroxysteroid 17-beta Dehydrogenase 4
Chromosome: CHR5: 118788137 -118878030
Locus: 5q23.1
POLK Gene Summary
This gene encodes a member of the DNA polymerase type-Y family of proteins. The encoded protein is a specialized DNA polymerase that catalyzes translesion DNA synthesis, which allows DNA replication in the presence of DNA lesions. Human cell lines lacking a functional copy of this gene exhibit impaired genome integrity and enhanced susceptibility to oxidative damage. Mutations in this gene that impair enzyme activity may be associated with prostate cancer in human patients. [provided by RefSeq, Sep 2016]
Gene Name: DNA Polymerase Kappa
Chromosome: CHR5: 74807656 -74895646
Locus: 5q13.3
Gene Diseases
The POLK HSD17B4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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