POLR1A-SETD2 Fusion FISH Probe
The POLR1A-SETD2 Fusion FISH Probe is used to confirm a fusion of the POLR1A and SETD2 genes. The fusion of the POLR1A and SETD2 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLR1A-SETD2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-RERE | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-REOR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-REGO | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-REGR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-REAQ | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-ORRE | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-OROR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-ORGO | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GORE | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GOOR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GOGO | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GOGR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GRRE | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GROR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GRGO | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GRGR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-AQRE | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-AQOR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-AQGO | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-AQGR | 20 (40 μL) | 200 μL |
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| POLR1A-SETD2-20-AQAQ | 20 (40 μL) | 200 μL |
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POLR1A Gene Summary
The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]
Gene Name: RNA Polymerase I Subunit A
Chromosome: CHR2: 86253450 -86333278
Locus: 2p11.2
SETD2 Gene Summary
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
Gene Name: SET Domain Containing 2
Chromosome: CHR3: 47057897 -47205467
Locus: 3p21.31
Gene Diseases
The POLR1A SETD2 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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