POLR1B-NRXN2 Fusion FISH Probe
The POLR1B-NRXN2 Fusion FISH Probe is used to confirm a fusion of the POLR1B and NRXN2 genes. The fusion of the POLR1B and NRXN2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLR1B-NRXN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-RERE | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-REOR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-REGO | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-REGR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-REAQ | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-ORRE | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-OROR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-ORGO | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GORE | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GOOR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GOGO | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GOGR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GRRE | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GROR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GRGO | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GRGR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-AQRE | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-AQOR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-AQGO | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-AQGR | 20 (40 μL) | 200 μL |
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| POLR1B-NRXN2-20-AQAQ | 20 (40 μL) | 200 μL |
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NRXN2 Gene Summary
This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010]
Gene Name: Neurexin 2
Chromosome: CHR11: 64373645 -64490660
Locus: 11q13.1
POLR1B Gene Summary
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]
Gene Name: RNA Polymerase I Subunit B
Chromosome: CHR2: 113299491 -113334727
Locus: 2q14.1
Gene Diseases
The POLR1B NRXN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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