POLR2F-MXI1 Fusion FISH Probe
The POLR2F-MXI1 Fusion FISH Probe is used to confirm a fusion of the POLR2F and MXI1 genes. The fusion of the POLR2F and MXI1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLR2F-MXI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-RERE | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-REOR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-REGO | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-REGR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-REAQ | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-ORRE | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-OROR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-ORGO | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GORE | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GOOR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GOGO | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GOGR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GRRE | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GROR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GRGO | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GRGR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-AQRE | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-AQOR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-AQGO | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-AQGR | 20 (40 μL) | 200 μL |
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| POLR2F-MXI1-20-AQAQ | 20 (40 μL) | 200 μL |
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MXI1 Gene Summary
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Gene Name: MAX Interactor 1, Dimerization Protein
Chromosome: CHR10: 111967362 -112047123
Locus: 10q25.2
POLR2F Gene Summary
This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: RNA Polymerase II Subunit F
Chromosome: CHR22: 38349673 -38365319
Locus: 22q13.1
Gene Diseases
The POLR2F MXI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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