POLR3B-PDS5B Fusion FISH Probe
The POLR3B-PDS5B Fusion FISH Probe is used to confirm a fusion of the POLR3B and PDS5B genes. The fusion of the POLR3B and PDS5B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| POLR3B-PDS5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-RERE | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-REOR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-REGO | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-REGR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-REAQ | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-ORRE | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-OROR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-ORGO | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GORE | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GOOR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GOGO | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GOGR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GRRE | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GROR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GRGO | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GRGR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-AQRE | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-AQOR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-AQGO | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-AQGR | 20 (40 μL) | 200 μL |
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| POLR3B-PDS5B-20-AQAQ | 20 (40 μL) | 200 μL |
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PDS5B Gene Summary
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Gene Name: PDS5 Cohesin Associated Factor B
Chromosome: CHR13: 33160563 -33352158
Locus: 13q13.1
POLR3B Gene Summary
This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: RNA Polymerase III Subunit B
Chromosome: CHR12: 106751435 -106903976
Locus: 12q23.3
Gene Diseases
The POLR3B PDS5B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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