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PPARD-WNK4 Fusion FISH Probe

The PPARD-WNK4 Fusion FISH Probe is used to confirm a fusion of the PPARD and WNK4 genes. The fusion of the PPARD and WNK4 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PPARD-WNK4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PPARD-WNK4-20-RERE 20 (40 μL) 200 μL
PPARD-WNK4-20-REOR 20 (40 μL) 200 μL
PPARD-WNK4-20-REGO 20 (40 μL) 200 μL
PPARD-WNK4-20-REGR 20 (40 μL) 200 μL
PPARD-WNK4-20-REAQ 20 (40 μL) 200 μL
PPARD-WNK4-20-ORRE 20 (40 μL) 200 μL
PPARD-WNK4-20-OROR 20 (40 μL) 200 μL
PPARD-WNK4-20-ORGO 20 (40 μL) 200 μL
PPARD-WNK4-20-ORAQ 20 (40 μL) 200 μL
PPARD-WNK4-20-GORE 20 (40 μL) 200 μL
PPARD-WNK4-20-GOOR 20 (40 μL) 200 μL
PPARD-WNK4-20-GOGO 20 (40 μL) 200 μL
PPARD-WNK4-20-GOGR 20 (40 μL) 200 μL
PPARD-WNK4-20-GOAQ 20 (40 μL) 200 μL
PPARD-WNK4-20-GRRE 20 (40 μL) 200 μL
PPARD-WNK4-20-GROR 20 (40 μL) 200 μL
PPARD-WNK4-20-GRGO 20 (40 μL) 200 μL
PPARD-WNK4-20-GRGR 20 (40 μL) 200 μL
PPARD-WNK4-20-GRAQ 20 (40 μL) 200 μL
PPARD-WNK4-20-AQRE 20 (40 μL) 200 μL
PPARD-WNK4-20-AQOR 20 (40 μL) 200 μL
PPARD-WNK4-20-AQGO 20 (40 μL) 200 μL
PPARD-WNK4-20-AQGR 20 (40 μL) 200 μL
PPARD-WNK4-20-AQAQ 20 (40 μL) 200 μL

PPARD Gene Summary

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

Gene Name: Peroxisome Proliferator Activated Receptor Delta

Chromosome: CHR6: 35310334 -35395968

Locus: 6p21.31

WNK4 Gene Summary

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]

Gene Name: WNK Lysine Deficient Protein Kinase 4

Chromosome: CHR17: 40932648 -40949084

Locus: 17q21.2

Gene Diseases

The PPARD WNK4 Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.