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PPFIBP1-PDILT Fusion FISH Probe

The PPFIBP1-PDILT Fusion FISH Probe is used to confirm a fusion of the PPFIBP1 and PDILT genes. The fusion of the PPFIBP1 and PDILT genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
PPFIBP1-PDILT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-RERE 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-REOR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-REGO 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-REGR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-REAQ 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-ORRE 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-OROR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-ORGO 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-ORAQ 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GORE 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GOOR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GOGO 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GOGR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GOAQ 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GRRE 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GROR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GRGO 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GRGR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-GRAQ 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-AQRE 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-AQOR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-AQGO 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-AQGR 20 (40 μL) 200 μL
PPFIBP1-PDILT-20-AQAQ 20 (40 μL) 200 μL

PPFIBP1 Gene Summary

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Name: PPFIA Binding Protein 1

Chromosome: CHR12: 27677044 -27848497

Locus: 12p11.23-p11.22

PDILT Gene Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has has an N-terminal ER-signal sequence, two thioredoxin (TRX) domains with non-classical Ser-Lys-Gln-Ser and Ser-Lys-Lys-Cys motifs, respectively, two TRX-like domains, and a C-terminal ER-retention sequence. The protein lacks oxidoreductase activity in vitro and probably functions as a chaperone. This gene's expression appears to be limited to the testis. [provided by RefSeq, Dec 2016]

Gene Name: Protein Disulfide Isomerase Like, Testis Expressed

Chromosome: CHR16: 20370491 -20416033

Locus: 16p12.3

Gene Diseases

The PPFIBP1 PDILT Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.